The Production of Homozygous Deficient Tissues with Mutant Characteristics by Means of the Aberrant Mitotic Behavior of Ring-Shaped Chromosomes.

:.HE PRODUCTION OF HOMOZYGOUS DEFICIENT TISSUES ,’ WITH MUTAST CHARACTERISTICS BY ME-AX’S OF i \ THE ABERRANT MITOTIC BEHAVIOR OF RING-SHAPED CHROMOSOIMES*

Efficient Production of Biallelic RAG1 Knockout Mouse Embryonic Stem Cell Using CRISPR/Cas9

Background: Recombination Activating Genes (RAG) mutated embryonic stem cells are (ES) cells which are unable to perform V (D) J recombination. These cells can be used for generation of immunodeficient mouse. Creating biallelic mutations by CRISPR/Cas9 genome editing has emerged as a powerful technique to generate site-specific mutations in different sequences. Ob...

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

Neuroblast cells in larvae homozygous for mutant alleles of the locus polo show a high frequency of metaphases in which the chromosomes have a circular arrangement, and anaphase figures in which chromosomes appear to be randomly oriented with respect to at least one of the spindle poles. These defects appear to lead to the production of polyploid cells. Sex chromosome disjunction is affected in...

A Novel Small E–Ring Shaped Monopole Antenna with Dual Band-Notch Function for UWB Wireless Communications

This paper presents an E-ring shaped printed monopole antenna for UWB applications with dual notched bands performance. In order to generate single frequency band notch function, we applied a U-ring shaped monopole antenna, and by inserting a rectangular ring in the centre of it an E-ring shaped radiating patch created and a dual band-notch function can be achieved. The measured bandwidth of th...

P-230: Analysis of TEX15 Expression in Testis Tissues of Severe Oligozoospermic and Non-Obstructive Azoospermic Men Referred to Royan Institute

Background: TEX15 is a novel protein that is required for chromosomal synapsis and meiotic recombination. Human TEX15 is located on chromosome 8(8p12 region) and expressed in testis and ovary, as is its mouse ortholog. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15 deficient spermatocytes exhibit a failure in chromosomal synapsis. In ...